
Tardive Dyskinesia
By Madison Gesualdo
Tardive dyskinesia is a syndrome in which a person exhibits repetitive, involuntary muscle movements. This syndrome directly affects the central nervous system and is typically seen in patients who are prescribed antipsychotic drugs, usually for bipolar disorder and schizophrenia. Tardive dyskinesia is chronic, with the Diagnostic and Statistical Manual of Mental Disorders Fifth Edition mandating that symptoms must persist for at least a month after an individual discontinues his or her medication in order to be officially diagnosed.
Neuroleptic drugs, also known as antipsychotics, are the most common inducers of tardive dyskinesia. Antipsychotics are often prescribed to patients with bipolar disorder and schizophrenia in order to reduce symptoms such as hallucinations, delusions, and disorganized thinking. These drugs successfully work by blocking receptors in the nervous system – specifically D2 dopamine receptors in the midbrain and forebrain – and consequently lowering dopamine levels within an individual. This is crucial for individuals diagnosed with bipolar disorder or schizophrenia because overactivity of dopamine in the brain can alter brain chemistry, leading to many of the psychotic symptoms associated with these disorders. Thus, antipsychotic medications are able to help assuage some of these symptoms by regulating an individual’s dopamine levels.
Like most medications, neuroleptic drugs have the potential for negative side effects. A person who has been taking neuroleptic drugs for an extended period of time may start experiencing abnormal involuntary movements, contractions, tics, tremors, and restlessness. All of these actions, in the context of long-term antipsychotic use, encompass tardive dyskinesia. These symptoms occur as the result of dopamine receptors having been blocked for too long; blockade of these receptors prevents fluid communication between nerve cells, resulting in a lack of stable movements in an individual.
If an individual finds that he or she is experiencing medication-induced tardive dyskinesia, he or she should consider talking to a doctor about stopping or switching the current medication that is causing it. Additionally, deep brain stimulation can also be utilized as a solution. This procedure employs a neurostimulating device that sends electrical signals into the brain to stimulate the blocked dopamine receptors and encourage movement.
Tardive dyskinesia should not be disregarded, as there are plenty of methods of intervention that can help reduce symptoms within an individual and make the condition more manageable. Make sure to consult with a healthcare provider about a treatment plan if you or a loved one is experiencing this condition.
If you or someone you know is struggling with their mental health, please contact our psychotherapy offices in New York or New Jersey to talk to one of our licensed professional psychologists, psychiatrists, psychiatric nurse practitioners, or psychotherapists at Arista Counseling & Psychotherapy. Contact our Paramus, NJ or Manhattan, NY offices respectively, at (201) 368-3700 or (212) 722-1920 to set up an appointment. For more information, please visit https://aristapsychiatrypsychotherapy.com/
References:
Allarakha, S. (n.d.) Why do antipsychotics cause tardive dyskinesia? MedicineNet. www.medicinenet.com/why_do_antipsychotics_cause_tardive_dyskinesia/article.htm
Ameer, M.A., Patel, P., & Saadabadi, A. Neuroleptic Medications. [Updated 2024 Feb 21]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK459150/
American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). https://doi.org/10.1176/appi.books.9780890425596
Bhandari, S. (2023, January 12). What is tardive dyskinesia? WebMD. https://www.webmd.com/mental-health/tardive-dyskinesia
Cornett, E.M., Novitch, M., Kaye, A.D., Kata, V., & Kaye, A.M. (2017) Medication-induced tardive dyskinesia: A review and update. The Ochsner Journal, 17(2), 162-174. https://www.ochsnerjournal.org/content/17/2/162/tab-article-info
The Centre for Addiction and Mental Health. (n.d.) Antipsychotic medication. CAMH. www.camh.ca/en/health-info/mental-illness-and-addiction-index/antipsychotic-medication#header.
Vasan, S., & Padhy, R.K. Tardive Dyskinesia. [Updated 2023 Apr 24]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK448207/









